Chick Young and Wilbur Grey are baggage handlers who receive the remains of Dracula and Frankenstein, bound for the House of Horrors museum. When Dracula and Frankenstein escape, complete chaos ensues as Chick and Wilbur get mixed up in an evil plot to switch Wilbur's brain with Frankenstein's and are aided by Larry Talbot, who turns into The Wolf Man when the moon is full!