A remake of the superhit Telugu movie Mathrudevobhava, Tulsi is about a couple, Tulsi (Manisha Koirala) and Suraj (Irrfan Khan,) who are parents to four kids. The life of this family is disrupted when Suraj is murdered. Another tragedy soon befalls them when Tulsi is diagnosed with blood cancer. Tulsi then makes it her mission to find good families willing to adopt her kids before she passes away.